The complex nature of transcription regulation can be investigated with various methods and under different angles. Systems Biology approaches allow us to get a holistic and systemic view on regulation of gene expression by bringing together and combining various perspectives, from signal transduction to transcription factors (TFs)- and chromatin-mediated gene regulation, to network inference.
This meeting aims at bringing together researchers representing the views on the process of transcription regulation from different perspectives, from the regulation of expression through transcription factors (TFs) to the field of chromatin structure, remodeling and its involvement in the regulation. We will welcome stories of success, discussions of actual problems and of methodology development, which is an actual issue in this field.
The first edition of this satellite workshop was held during the 17th edition of the International Conference on Systems Biology in Barcelona (Spain) on 2016, achieving a very good public success with an excellent panel of speakers, interactive discussions at both the talks and poster sessions, and a highly appreciated round table.
For this second edition, we would like to structure the workshop in two sessions: the first one would be dedicated to all variety of Systems Biology approaches to transcription regulation, for instance, but not limited to, data deconvolution, dynamical modeling, network inference, etc. The second session would focus on the impact of chromatin structure and histone modifications on gene expression and how this layer of regulation is incorporated in Systems Biology approaches. Additionally, we plan to end the workshop with a round table for discussion on how to address most actual problems, from methodology use to data analyses.
In the Workshop Systems Biology of Transcription Regulation we therefore welcome efforts
- Signals to transcription: signaling pathways triggered by receptors and aiming TFs or
- TF-mediated regulation: TFs, binding of a TF to DNA, TFBSs, motifs, etc.
- Chromatin-histone level: impact of chromatin structure and histone modifications on the gene
- Mathematical modeling of the dynamic behavior of gene regulatory networks
- Multilevel modeling: bringing together data from different “levels”, e.g., different –omics
data; multilayer networks; combining chromatin and TF information; etc.
We will appreciate abstracts representing the views on the process of transcription regulation from
different perspectives and different angles, preferably combining the abovementioned issues.
Systems biology approaches provide new perspectives that raise new questions. Some of them address
methodological problems, others arise from the newly obtained understanding of the data. These open
questions and problems will be a subject of discussion in the Round Table (see Agenda).
Registration and submission are closed.
You are invited to submit a one-page abstract
that will be reviewed and selected for a 20-minute talk, short talk (10
min) or poster. The abstract should include all authors' names with
affiliations (please mark the presenting author with an asterisk).
Confirmation receipt will be sent on request.